About aria-mcp-server
ARIA is an MCP server for biomedical researchers and clinical trial teams, providing searches across PubMed, ClinicalTrials.gov, and ISRCTN without API keys. It also includes research prompts and reference resources.
Key features
- 01Search PubMed literature
- 02Search ClinicalTrials.gov trials
- 03Search ISRCTN trials
- 04Use structured research prompts
- 05Access trial and regulatory references
Use cases
- 01Find biomedical papers on a condition or treatment
- 02Identify recruiting trials for a disease
- 03Review drug safety evidence and adverse events
- 04Check eligibility across recruiting trials
MCP support
Exposes literature and trial search tools, research prompts, and reference resources to MCP clients.
Configuration
Local server config is the same for every client. Copy it into your client’s MCP config file.
Tools
3Saved tool list · updated 2w ago
| Parameter | Type | Required | Description |
|---|---|---|---|
| query | string | Yes | Search query e.g. 'velarixin pediatric epilepsy phase 2' |
| max_results | integer | No | Number of papers to return, between 1 and 10 |
Details
From the project README🧬 ARIA Clinical Research MCP Server
A standalone MCP server that gives any Claude agent real-time access to biomedical literature and clinical trials — no API keys required.
Tools
| Tool | Description |
|---|---|
search_pubmed | Search 35M+ peer-reviewed papers via NCBI E-utilities |
search_clinical_trials | Search 400K+ trials via ClinicalTrials.gov v2 API |
search_isrctn | Search UK/European trials via ISRCTN registry |
Prompts
| Prompt | Description |
|---|---|
clinical-research-brief | Comprehensive evidence + trial brief for a condition |
adverse-event-analysis | Structured AE and safety profile for a drug |
trial-eligibility-checker | Patient eligibility assessment across recruiting trials |
Resources
| Resource | Description |
|---|---|
info://aria | Overview of ARIA capabilities and data sources |
reference://trial-phases | Phase I–IV definitions and FDA special designations |
reference://high-impact-journals | Curated high-impact journals by specialty |
reference://fda-databases | FDA databases for drug, safety, and regulatory research |
Example queries
Once connected, ask Claude:
- "Search PubMed for ketogenic diet pediatric epilepsy outcomes"
- "Find recruiting trials for lung cancer immunotherapy"
- "What does the literature say about veliparib in ovarian cancer, and are there active trials?"
- "Find UK and European trials for pediatric epilepsy via ISRCTN"
Quickstart
pip install aria-mcp-server
aria-mcp-server
Connect to Claude Desktop
Add to ~/Library/Application Support/Claude/claude_desktop_config.json:
{
"mcpServers": {
"aria-clinical-research": {
"command": "aria-mcp-server"
}
}
}
Restart Claude Desktop. The server will appear under Settings → Developer → Local MCP Servers.
Data sources
- PubMed — NCBI E-utilities (public API, no key required)
- ClinicalTrials.gov — v2 REST API (public API, no key required)
- ISRCTN — UK/European clinical trials registry (public API, no key required)
Tech stack
- FastMCP — MCP server framework
- Python 3.12+
Use cases
- Life sciences researchers needing real-time literature access
- Clinical trial coordinators checking eligibility and recruiting status
- Drug discovery teams cross-referencing published evidence with active trials
- Any Claude agent needing grounded biomedical knowledge
Project Structure
aria-mcp-server/ ← root, where mcp-publisher runs
├── aria_mcp_server/ ← Python package
│ ├── __init__.py
│ ├── server.py
│ └── tools.py
├── server.json ← MCP registry metadata
├── pyproject.toml
├── README.md
├── LICENSE
└── glama.json
Built by
Pooja Kotecha · dinq.me/pkotecha-eng
Comments
New to MCP?
From what the protocol is to installing your first server, these answers cover most first questions.
An open protocol that defines how AI applications connect to external tools and data in a uniform way. Clients talk to the model; MCP servers provide tools, resources and prompt templates. They exchange standard messages, so one server can be reused by many clients.