Skills
97,222 packaged capabilities and playbooks for agents. Install any of them with one command.
Data & databases
When the user wants to plan, design, or implement an A/B test or experiment. Also use when the user mentions "A/B test," "split test," "experiment," "test this change," "variant copy," "multivariate test," or "hypothesis." For tracking implementation, see analytics-tracking.
scikit-learn compatible Python toolkit for time series ML: classify, cluster, regress, segment, transform with 30+ algorithms (ROCKET, InceptionTime, KNN-DTW, HIVE-COTE, WEASEL). Handles panel, multivariate, and unequal-length series. Maintained successor to sktime. Alternatives: sktime (larger ecosystem), tslearn (fewer algorithms), catch22 (features only).
DTC data dashboards and health checks — three-layer dashboards, KPI tracking, north star, anomaly alerts. Triggers: 数据体检, 仪表盘, dashboard, KPI, 指标追踪, 基准线, 营收报表, 异常预警, metrics, benchmark, data health check, revenue report. Route complex questions through afa first.
Access the AlphaFold DB of 240M+ AI-PREDICTED protein structures (v6, plus precomputed homodimer/heterodimer complexes) — retrieve models by UniProt accession, download PDB/mmCIF files, and analyze prediction confidence metrics (pLDDT, PAE). Use when a UniProt ID needs a computationally predicted 3D structure or when no experimental structure exists, for homology modeling, protein engineering, or structure-based drug discovery; for EXPERIMENTALLY determined structures (X-ray, cryo-EM, NMR) prefer alterlab-pdb, to fold a NEW sequence or complex yourself prefer alterlab-alphafold, and for protein sequences, annotations, or accession ID mapping prefer alterlab-uniprot instead. Part of the AlterLab Academic Skills suite.
Query cBioPortal via its keyless REST API for cancer genomics across TCGA, GENIE, MSK-IMPACT and hundreds of studies — somatic mutations, copy-number alterations (GISTIC), mRNA/protein expression, structural variants, and patient-level clinical/survival data. Use when asked how often a gene is mutated/amplified/deleted in a tumor type, to profile oncogenes or tumor suppressors across cancers (pan-cancer alteration frequency), to pull patient-level mutations joined to OS/clinical outcomes, or to validate a cancer target from cohort genomics. For germline variant pathogenicity use alterlab-clinvar; for mutational-signature (SBS) decomposition use alterlab-cosmic; for CRISPR/RNAi gene-dependency use alterlab-depmap; for aggregated target-disease evidence use alterlab-opentargets. Part of the AlterLab Academic Skills suite.
Process and visualize deep-sequencing coverage with the deepTools CLI — convert BAM to bigWig (bamCoverage), build log2 ratio tracks (bamCompare), run QC (multiBamSummary correlation, PCA, plotFingerprint), apply the ATAC-seq Tn5 shift (alignmentSieve --ATACshift), and make TSS/peak heatmaps and profiles (computeMatrix, plotHeatmap, plotProfile). Use for coverage tracks, signal heatmaps/profiles, normalization (RPGC/CPM/RPKM), and effective-genome-size lookups for ChIP-seq, ATAC-seq, MNase-seq, or RNA-seq. NOT for per-read/CIGAR/MAPQ BAM record access — that is pysam. Part of the AlterLab Academic Skills suite.
Access NCBI GEO (Gene Expression Omnibus) for gene expression and functional genomics data — search and download microarray and RNA-seq datasets by GSE, GSM, GPL, or GDS accession and retrieve SOFT, MINiML, and series matrix files. Use when locating public expression datasets, fetching processed expression matrices, downloading a study's supplementary files, or sourcing per-study transcriptomics data for differential-expression analysis. For raw FASTQ sequencing reads by SRA/ENA run accession use alterlab-ena; for reference tissue-expression baselines (median TPM across human tissues) use alterlab-gtex; for cancer cohort somatic mutations and copy-number use alterlab-cbioportal. Part of the AlterLab Academic Skills suite.
Run fast one-liner queries to 20+ bioinformatics databases from the gget CLI or Python — gene info (Ensembl), BLAST, AlphaFold structures, Enrichr enrichment, and more. Use for quick interactive lookups of genes, sequences, structures, or pathways — for batch processing or advanced BLAST use biopython, for multi-database Python workflows use bioservices. Part of the AlterLab Academic Skills suite.
Query the NHGRI-EBI GWAS Catalog REST API v2 for curated SNP-trait associations, retrieving variants by rs ID, disease/trait (EFO/MONDO), gene, or study (GCST) with p-values, effect sizes, and ancestry, and locate full harmonised summary statistics on the FTP site. Use when investigating genome-wide association study hits, mapping a SNP or rsID to traits, selecting GWAS for polygenic risk scores or fine-mapping, or doing genetic epidemiology lookups. Part of the AlterLab Academic Skills suite.
Build phylogenetic trees end-to-end from raw sequences — MAFFT multiple sequence alignment, optional TrimAl trimming, IQ-TREE 3 maximum-likelihood inference with model selection and bootstraps, FastTree for large datasets, then visualize with ETE3 or FigTree. Use when reconstructing trees from sequences (FASTA) for evolutionary analysis, microbial genomics, viral phylodynamics, protein-family studies, or molecular-clock dating. For manipulating/comparing an EXISTING Newick tree (prune, root, Robinson-Foulds, duplication/speciation events) use alterlab-etetoolkit; for plain sequence parsing/translation use alterlab-biopython. Part of the AlterLab Academic Skills suite.
Store and query genomic variant data at scale with TileDB-VCF — ingest VCF/BCF into compressed TileDB arrays, add samples incrementally, run fast parallel region/sample queries, and export back to VCF. Use when managing population-genomics variant datasets that are too large for flat VCF, building joint variant stores, or querying thousands of samples by region. Part of the AlterLab Academic Skills suite.
Query bioRxiv/medRxiv preprints via REST API. Search by DOI, category, or date range; retrieve metadata (title, abstract, authors, category, DOI, version history) and PDFs. No auth. For peer-reviewed biomedical use pubmed-database; broader scholarly search use openalex-database.
BRENDA Enzyme DB SOAP/REST queries: kinetic parameters (Km, Vmax, kcat, Ki), EC classes, substrate specificity, inhibitors, cofactors, organism data. 80K+ enzymes, 7M+ values. Free academic registration. For metabolic modeling use cobrapy-metabolic-modeling; metabolites use hmdb-database.
Refresh and update existing A-share investment presentation decks with latest data. Adapts the original deck-refresh skill for Chinese presentations, A-share data updates, and domestic market conventions. Triggers on "更新PPT", "刷新演示", "refresh deck China", "update presentation", "更新演示文稿", or "refresh slides [company]".
Create professional Excel workbooks for A-share financial analysis. Adapts the original xlsx-author skill for Chinese financial modeling standards, CAS conventions, and A-share formatting. Triggers on "A股Excel模型", "财务模型制作", "create model China", "build model xlsx", "制作模型", or "Excel model [company]".
Clean readable web fetch for modern pages, with WeChat cleanup, markdown output, batch fetch, selector overrides, and support for many hard-to-fetch pages. Fetches clean, readable body content from modern web pages, supports WeChat official account article fetching and trailing noise cleanup, reducing useless information and token consumption; suitable for news, blogs, announcements, and many pages where ordinary fetch is unstable or hindered by anti-scraping or dynamic rendering.
Provides comprehensive guidance for Tencent Cloud CDB including database creation, configuration, backups, and CDB management. Use when the user asks about Tencent Cloud CDB, needs to create CDB databases, configure CDB, or manage Tencent Cloud database services.
Write and debug Flink SQL that runs on Confluent Cloud, enforcing the CC-vs-Apache-Flink (OSS) dialect boundary. Use when the working directory is a Confluent Cloud Flink workspace, when a Flink SQL statement needs checking before it runs on a CC compute pool, or when the user mentions CC Flink, Confluent Cloud Flink SQL, the `confluent flink` CLI, a CFU compute pool, `CREATE CONNECTION`, or asks to check or debug Flink SQL whose runtime is Confluent Cloud. Also trigger when a Flink SQL question is posed and nothing establishes an Apache Flink OSS runtime. Do NOT trigger for: building or deploying Flink UDFs in Java (UDF/UDTF/PTF — use flink-udf); a full CDC pipeline from a database through Flink into Tableflow/Iceberg/Delta Lake (use confluent-cloud-cdc-tableflow); Kafka Streams topology work (use kafka-streams-programming); or Flink SQL confirmed to run on Apache Flink OSS, not Confluent Cloud.
Helps write, fix, and optimize Crowdin CroQL expressions for strings, translations, TM segments, and glossary terms. Use whenever the user mentions CroQL, Crowdin filters, advanced editor filtering, "where" conditions for localization data, or API queries with a `croql` parameter, even if they do not explicitly ask for query syntax help.
Corrects the wrong defaults a model has when building Datadog dashboards, verified against Datadog's docs in July 2026. Use when creating, editing, or reviewing a Datadog dashboard — choosing widgets, writing metric/log/span queries, or emitting widget JSON. Covers the queries that render a plausible number and are still wrong — `.as_count()` is appended automatically in the graph editor but never through the API, so programmatic counts silently average; `p95` resolves only on distribution metrics, and averaging one is an average of averages; ratios need `.as_count()` on both sides or they divide interpolated averages. Also covers grounding queries in metrics that exist rather than invented names, wire type strings that diverge from UI names (Pie Chart is `sunburst`, Table is `query_table`), and Datadog's own layout standard. Assumes the Datadog MCP server is connected. NOT for Terraform or raw Dashboard API management, monitor and SLO authoring, or non-Datadog observability tools.
Audit horizontal scaling topology — declarative partitioning fit for large/time-series tables, hot-partition / skewed partition-key risk, and premature sharding that adds complexity before it is justified. Module M16. Feeds the Performance & Scale score.
Managed-platform fitness (M21) — checks the project against the realities of its hosting platform (Supabase, Neon, PlanetScale, Turso, Cloudflare D1, CockroachDB, Yugabyte, DynamoDB, RDS/Aurora). Engine version currency (without fabricating EOL dates), honest pricing / vendor lock-in trade-offs, and per-platform feature support — most importantly foreign-key support (PlanetScale Vitess historically restricts FKs; D1/SQLite, serverless drivers, connection limits). Feeds the Design & Integrity AND Performance & Scale scores.
Specialized-engine fitness (M20) — checks whether a vector, time-series/OLAP, graph, or search store is configured correctly for its job. M20a vector (dimensions match the embedding model, distance metric matches how the model was trained, HNSW/IVFFlat params present), M20b time-series/OLAP (hypertable/partition fit, continuous aggregates, compression), M20c graph (edge modeling, supernode risk, index-backed lookups), M20d search (analyzer/mapping, FTS config). Feeds the Design & Integrity AND Performance & Scale scores per sub-module.
Deneb visual creation, Vega/Vega-Lite spec authoring, and Deneb best practices for PBIR reports. Automatically invoke whenever the user mentions "Deneb" in any context, or asks about Vega/Vega-Lite specs in Power BI, Deneb cross-filtering, Deneb interactivity, pbiColor theme integration, Deneb field name escaping, or Deneb rendering issues.
ETE Toolkit (ETE3): Python phylogenetic tree analysis and visualization. Parse Newick/NHX/PhyloXML, traverse/annotate nodes, render figures with TreeStyle/NodeStyle, integrate NCBI taxonomy, run PhyloTree comparative genomics. Use for species trees, gene family evolution, annotated tree figures.
Framework for running single-variable cold email experiments. Defines experiment types (list-only, copy-only, combined), confidence weighting, minimum sample sizes, and success criteria. Use when the user wants to improve a campaign, test a new list vs old one, or compare copy variants. Prevents the #1 learning-loop mistake — changing list + copy + offer at once and losing all signal.
Explain a database schema, model, or a single finding in plain language, with a paradigm-aware diagram — what the tables/collections/keyspaces are, how they relate, and where the data lives. Read-only; teaches, does not change anything. Use when the user asks to explain, describe, walk through, draw, or diagram a schema, a data model, a relationship, or what a specific audit finding means.
Build and review assumptions-led financial models, unit economics, pricing, fundraising scenarios, and SaaS operating metrics. Use when calculating CAC, LTV, payback, runway, ARR, churn, NDR, Rule of 40, or sales efficiency; when modeling revenue, costs, cash flow, pricing, cap tables, or financing. Do not use this skill for unrelated requests; route to the nearest named specialist.
Classical end-to-end empirical analysis workflow in the traditional Stata ecosystem — native Stata + reghdfe + ivreg2 + csdid + did_imputation + eventstudyinteract + sdid + rdrobust + rddensity + synth + synth_runner + psmatch2 + teffects + ebalance + coefplot + esttab + asdoc + binscatter. **Defaults to economics empirical-paper style** (AER / QJE / AEJ) — every run produces a publication-ready output set with a multi-column regression table (M1→M6 progressive controls/FE) as the centerpiece, plus Table 1 (descriptives), mechanism / heterogeneity / robustness tables, and event-study + coefficient + trend figures. Covers the full 8-step Stata pipeline an applied economist runs on every paper — (1) data import & cleaning (use/import, destring, misstable, duplicates, merge assert), (2) variable construction (gen/egen/winsor2/xtile/xtset with L./F./D.), (3) descriptive statistics & Table 1 (tabstat/balancetable/asdoc), (4) classical diagnostic tests (sktest/swilk/hettest/imtest/xtserial/xttest3/vif/dfuller/kpss/hausman/estat overid), (5) baseline modeling (reg/xtreg/reghdfe/ivreg2/ivregress/csdid/did_imputation/eventstudyinteract/sdid/rdrobust/synth/psmatch2/teffects/heckman/qreg/ppmlhdfe), (6) robustness battery (bacondecomp/honestdid/rwolf/ritest/wildbootstrap/oster), (7) further analysis (subgroup/triple-diff/interactions/medsem/marginsplot/binscatter by group), (8) publication-ready tables & figures (esttab/outreg2/estout/coefplot/marginsplot/rdplot/twoway combined). **Also covers two parallel domain modes that share the same 8-step scaffolding** — **Mode A — Epidemiology / public health** (target-trial emulation, IPTW + g-formula + TMLE doubly-robust triplet via `teffects ipw` / `teffects ipwra` / `teffects aipw` / `eltmle`, Mendelian randomization via `mrrobust` (IVW / Egger / weighted median) and `mregger` / `mrpresso`, KM / Cox / AFT / RMST survival via `sts` / `stcox` / `streg` / `strmst2`, E-value sensitivity via `evalue` (Linden-Mathur), principal stratification — STROBE / TRIPOD reporting), and **Mode B — ML causal inference** (DML via `ddml` / `pdslasso`, S/T/X/R/DR meta-learners via `crforest` and `ddml interactive`, causal forest via `crforest` / `cforest`, BART/BCF via `bart` / `bartCause`-style externals, CATE distribution + policy tree via `crforest`, off-policy evaluation, conformal causal externals, fairness audit, DAG learning via `pcalg` / external Python callouts). Use when the user asks for a complete Stata empirical analysis, wants a reproducible .do-file pipeline, needs a Stata counterpart to the Python StatsPAI / Full-empirical-analysis-skill, or names a specific Stata step in isolation ("run reghdfe with two-way clustering", "csdid event study", "winsor2 at 1%", "esttab to LaTeX", "coefplot with CI", "ivreg2 weak-IV test", "synth_runner placebos", "teffects psmatch balance check"). Mode A triggers on "target trial emulation Stata", "teffects ipw aipw", "eltmle", "mrrobust", "mregger weighted median", "stcox AFT survival", "strmst2", "evalue Stata", "STROBE Stata", "公共健康 Stata", "流行病学 Stata". Mode B triggers on "ddml Stata", "pdslasso", "crforest causal forest Stata", "policy tree Stata", "因果机器学习 Stata".
This skill MUST be used when the user needs stock screening, portfolio risk review, dividend portfolio design, pre-earnings analysis, industry competition analysis, DCF valuation, technical analysis, or stock trend/anomaly detection. MUST trigger on requests like 選股, 投資組合風險, 股息策略, 財報前瞻, DCF 估值, 技術面分析, 產業競爭研究, 趨勢識別, or investment research prompts.
Use when user asks to create/design a big screen (大屏), full-screen data visualization, or says "创建大屏", "生成大屏", "新建大屏", "设计大屏", "做一个大屏", "BI大屏", "数据大屏", "可视化大屏", "监控大屏", "create big screen", "design big screen", "BI visualization big screen". Also triggers when user describes big screen requirements like "做一个销售数据大屏" or mentions full-screen display like "展厅展示", "监控室大屏". Make sure to use this skill for big screens (大屏) — NOT dashboards (仪表盘/看板), which use a completely different layout and styling system.
Open-source FAIR biology data framework. Version artifacts (AnnData, DataFrame, Zarr), track lineage, validate via ontologies (Bionty), query datasets. Integrates with Nextflow, Snakemake, W&B, scVI. For scRNA-seq use scanpy; for ontology lookups use bionty.
An Amazon Ads Sponsored Products (SP) insights reporting skill that uniformly retrieves two types of Amazon Ads Reporting API v1 beta reports: Audience segment performance and Search Term Impression Share/Rank. It automatically handles profile-to-advertiser-account mapping, report creation, status polling, multi-shard CSV download, and persistence to disk. Trigger only when the user explicitly requests SP audience reports, SP search term impression share, or impression share rank; ordinary SP search term performance reports and SB/SD/DSP reports must not trigger it. This skill depends on linkfox-amazon-ads-auth.
Lint a database migration for safety before it runs — classify lock level, table rewrite, and reversibility; flag destructive/blocking operations; and propose an expand-contract rollout. Read-only analysis by default; any data-loss step requires an explicit token handshake before the writer is involved. Use when the user asks to review, lint, check, or de-risk a migration, an ALTER/DROP, an enum change, a backfill, or a schema change before deploying.
Plan and execute safe cross-system migrations, including service extraction from monoliths. Use when moving data, schemas, interfaces, infrastructure, or service ownership through compatibility windows, dual-running, reconciliation, cutover, recovery, or deprecation. Do not use for deciding whether decomposition is justified, designing a target architecture, or implementing one named technology; route those to the relevant architecture or specialist skill.
Molecular featurization hub (100+ featurizers) for ML. SMILES to fingerprints (ECFP, MACCS, MAP4), descriptors (RDKit 2D, Mordred), pretrained embeddings (ChemBERTa, GIN, Graphormer), pharmacophores. Scikit-learn compatible with parallelization/caching. For QSAR, virtual screening, similarity, and molecular DL.
Python package for the creation, manipulation, and study of the structure, dynamics, and functions of complex networks. Supports various graph types (Directed, Undirected, Multigraphs) and features a vast library of standard graph algorithms. Use for network analysis, graph theory, social network analysis, biological networks, infrastructure networks, path finding, centrality measures, community detection, graph algorithms, shortest paths, PageRank, connectivity analysis, and routing optimization.
Coach the user on what to fix first — rank the audit findings into a single, ordered to-do list by score impact and effort, and explain why each item is where it is. Read-only; advises, does not change anything. Use when the user asks what to do next, what to fix first, what matters most, how to prioritize, or where to start after an audit.
New to MCP?
From what the protocol is to installing your first server, these answers cover most first questions.
An open protocol that defines how AI applications connect to external tools and data in a uniform way. Clients talk to the model; MCP servers provide tools, resources and prompt templates. They exchange standard messages, so one server can be reused by many clients.